We have developed a technique for the formation of stable dimeric complexes involving amyloid peptides, which tend to form amyloid plaques. One of the mechanisms responsible for the formation of amyloid plaques is the introduction of amyloid peptides into biochemical reactions on the way to achieving chemical and thermodynamic equilibrium.
We propose a technique for achieving equilibrium at the level of dimeric complexes, so that amyloid peptides will form lower molecular weight complexes to a lesser extent.
The technique developed by us is in good agreement with previously performed experimental work, namely, we were able to determine the key amino acid residues that introduce the greatest instability in amyloid complexes. As criteria determining the stability and stability of the biochemical complex, in this case, we measure the change in the differential entropy of the complex, as well as the value of lg (cond (W)).
Our technique allows us to find combinations of dimers, which are characterized by greater stability and low reactivity.
In 2020, two articles will be published on amyloid peptides (publishing house: Springer Nature), as well as their inhibition, the articles will describe physical methods, examples of previously conducted biochemical experiments. In addition, amyloid peptide inhibitors are listed under the numbers N1, N2, N3.
At the moment, we have received a large amount of data on amyloid peptide inhibitors, we are conducting a fundraising company to conduct an experiment and create a database.
If you are interested in this topic, as well as the transfer of rights to the further use of the inhibitors found for scientific, practical, laboratory, pharmacological purposes, you can contact us and receive exclusive data with the transfer of use rights for
The offer will be valid until our group finds a sufficient amount of alternative financing.
So you can get exclusive rights to amyloid peptide inhibitors. Our development team is aware and liable for transferring confidential information to third parties for a nominal fee. Since the technique is unique, this offer can be withdrawn from the market at any time.