p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation.
Let us present the structure of the tetramerization domain of proteins P73. In this section, we carefully study the interaction between different sites, as well as between amino acid residues of polypeptide chains
Intaractions between «Yellow» tetramerisation domain of protein P73 and «Blue» tetramerisation domain of protein P73
The figure shows some amino acid residues that account for the maximum values of the potential energy of electrostatic interaction between two domains of two proteins P73. The maximum values fall almost symmetrically into two different tetramerization domains of P73
In the next section, we study the redistribution of interaction energies when replacing amino acid residues with alanine in the tetramerisation domain of protein P73