Structure of protein p73-p73

p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation.


Let us present the structure of the tetramerization domain of proteins P73. In this section, we carefully study the interaction between different sites, as well as between amino acid residues of polypeptide chains

Crystal structure of the human p73 tetramerization domain [PDB: 2WQI ]


Intaractions between «Yellow» tetramerisation domain of protein P73 and «Blue» tetramerisation domain of protein P73

Three-dimensional map of potential energy of electrostatic interaction between a «yellow» protein P73 and a» blue» protein P73
2D map of potential energy of electrostatic interaction between a «yellow» protein P73 and a «blue» protein P73
Value table between yellow protein P73 and a blue protein P73

The figure shows some amino acid residues that account for the maximum values of the potential energy of electrostatic interaction between two domains of two proteins P73. The maximum values fall almost symmetrically into two different tetramerization domains of P73


Orange-Green

Three-dimensional map of potential energy of electrostatic interaction between a «orange» protein P73 and a «green» protein P73
Value table between orange protein P73 and green protein P73

Yellow-Orange

Value table between orange protein P73 and yellow protein P73
Three-dimensional map of potential energy of electrostatic interaction between a orange protein P73 and yellow protein P73

Alaning Scaning

In the next section, we study the redistribution of interaction energies when replacing amino acid residues with alanine in the tetramerisation domain of protein P73

Three-dimensional map of potential energy of pairwise electrostatic interaction when replacing Y355A in «blue» tetradimerisation domain of P73 protein
Table of values of potential energies when replacing Y355A in «blue» tetradimerisation domain of P73 protein
Three-dimensional map of potential energy of pairwise electrostatic interaction when replacing Y356A in «blue» tetradimerisation domain of P73 protein
Table of values of potential energies when replacing Y356A in «blue» tetradimerisation domain of P73 protein
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