PD-1 in complex with nivolumab Fab

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PD-1 in complex with nivolumab Fab [5GGR]

Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers negative signals upon interaction with its two ligands, PD-L1 or PD-L2. PD-1 and its ligands are broadly expressed and exert a wider range of immunoregulatory roles in T cells activation and tolerance compared with other CD28 members. 

Nivolumab is a human monoclonal antibody to programmed cell death receptor 1 (PD-1), which modulates T cell immune reactivity and is used in the immunotherapy of cancer. Nivolumab has major side effects and particularly immune related conditions, including acute liver injury which can be serious and even life threatening.

The structure of the biological complex

You can now get a table of the values of the potential energy of electrostatic interaction between PD-1 and FAB1 just for 156 EURO

Table1 of potential energies of pairwise electrostatic interaction between PD1 and FAB1. Exel.
Table1-2 of potential energies of pairwise electrostatic interaction between PD1 and FAB1. Exel.

You can also download a table of the values of the potential energy of electrostatic interaction between PD-1 and FAB2 just for 156 EURO

Table2 of potential energies of pairwise electrostatic interaction between PD1 and FAB2. Exel.

You can order alanine scanning or mutagenesis (from 15 substitutions of amino acid residues) from 3500 Euro. A detailed study of the properties of the protein complex Fab1-Fab2-PD1 from 7890 Euro

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